Yasuyuki Goto, PhD

Scientist I

Yasuyuki Goto was born in Miyazaki, Japan. He obtained a BSc from University of Tokyo in 1999. His postgraduate studies were performed at the School of Agricultural and Life Sciences, University of Tokyo. During his postgraduate period his interests were focused on parasitic diseases such as leishmania and malaria. His PhD thesis, entitled "Studies on innate immunity in the pathogenesis of cutaneous leishmaniasis," was completed in March 2004. In April 2004 Yasuyuki joined IDRI as a Postdoctoral scientist.

Yasuyuki is currently working toward the development of vaccines, diagnostics, and immunotherapeutics against leishmaniasis, a project funded by the Bill & Melinda Gates Foundation and the National Institutes of Health.

Recent Publications

1.      Goto Y, Carter D, Reed SG. 2008. Immunological Dominance of Trypanosoma cruzi Tandem Repeat Proteins. Infect Immun 76:3967-3974.
2.      Fox CB, Anderson RC, Dutill TS, Goto Y, Reed SG, Vedvick TS. 2008. Monitoring the Effects of Component Structure and Source on Formulation Stability and Adjuvant Activity of Oil-in-Water Emulsions. Colloids Surf B Biointerfaces 65:98-105.
3.      Goto Y, Sanjoba C, Asada M, Saeki K, Onodera T, Matsumoto Y. 2008. Adhesion of MRP8/14 to amastigotes in skin lesions of Leishmania major-infected mice. Exp Parasitol 119:80-86.
4.      Vedvick TS, Carter L, Moulton G, Goto Y, Bertholet S, Reed SG, Carter D. 2008. An Improved Manufacturing Process for a Recombinant Polyprotein Vaccine: Combating the devastating global disease of leishmaniasis with a new therapeutic and prophylactic vaccine. Biopharm Int Supplement to Januanry 2008: 14-22.
5.      Goto Y, Bogatzki LY, Bertholet S, Coler RN, Reed SG. 2007. Protective immunization against visceral leishmaniasis using Leishmania sterol 24-c-methyltransferase formulated in adjuvant. Vaccine 25:7450-7458.
6.      Coler RN, Goto Y, Bogatzki L, Raman V, Reed SG. 2007. Leish-111f, a Recombinant Polyprotein Vaccine that Protects against Visceral Leishmaniasis by the elicitation of CD4+ T cells. Infect Immun 75:4648-4654.
7.      Goto Y, Sanjoba C, Arakaki N, Okamoto M, Saeki K, Onodera T, Ito M, Matsumoto Y. 2007. Accumulation of macrophages expressing MRP8 and MRP14 in skin lesions during Leishmania major infection in BALB/c and RAG-2 knockout mice. Parasitol Int 56:231-234.
8.      Goto Y, Coler RN, Reed SG. 2007. Bioinformatic identification of tandem repeat antigens of Leishmania donovani complex. Infect Immun 75:846-851.