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Chagas Disease

Need

Description: Sample College Image Prevalent in Latin America, Chagas disease is a potentially life-threatening illness caused by the parasite T. cruzi, which is most commonly transmitted through insects known as “kissing bugs.” The infection may trigger a chronic inflammatory disease in 30% of individuals. If left untreated, the disease usually impairs the heart and digestive system; it is a leading cause of heart disease in Latin America. In adults, the decline in health develops slowly, occurring 20-30 years after the initial infection.

Chagas disease is found mainly in endemic areas of 21 Latin American countries. About 6-7 million people worldwide are estimated to be infected. In pregnancy, however, the disease can be devastating; congenital infection with T. cruzi can cause miscarriage, stillbirth and newborn death. Though the disease was once entirely confined primarily to Latin America, the disease has now spread to other continents and cases have been reported in the U.S.

Because T. cruzi infection can persist in asymptomatic adults for many years, the parasite has contaminated the blood supply in many areas of Latin America. Therefore, blood screening is vital to prevent infectious through transfusion and organ transplantation.

Focus

IDRI is pursuing a multi-faceted approach to eliminating Chagas disease, including developing diagnostics that screen the blood supply for T. cruzi, the parasite that causes Chagas disease, as well as diagnostic tests that effectively detect T. cruzi infection.

In 2010 the U.S. FDA approved a test that utilizes IDRI technology to screen blood and organ donations for T. cruzi. This is one of only two FDA approved Chagas tests, and it is an important part of the screening procedures that help to maintain the safety of the blood supply. Our proprietary recombinant fusion protein is now being used in tests to diagnose Chagas Disease in the U.S. and Latin America. IDRI is developing new antigenic proteins to improve diagnosis.



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