Tanya Parish, PhD

Director, Drug Discovery

 

Professor Tanya Parish joined IDRI in November 2007. She is currently the Director of Drug Discovery and is responsible for the TB Discovery Research group. Work in this group encompasses a range of early stage drug discovery including drug target identification and validation, high throughput screening and medicinal chemistry. Tanya is also an Affiliate Professor in the Department of Global Health at the University of Washington.

Tanya has expertise in the molecular genetics and the microbiology of the mycobacteria. Her interests include drug target validation and the development of novel genetic methods for Mycobacterium tuberculosis (Mtb).

Tanya studied for her PhD at the National Institute for Medical Research with Philip Draper, where she investigated gene regulation in mycobacteria. She subsequently conducted post-doctoral research at the London School of Hygiene & Tropical Medicine with Neil Stoker, studying several facets of the biology of M. tuberculosis. In 2000, she took up an academic post at Barts and the London, Queen Mary’s School of Medicine and Dentistry (UK), where she still holds a post as Professor of Mycobacteriology. She still maintains an active research group in London, investigating the biology and pathogenesis of M. tuberculosis. 
 

(http://www.icms.qmul.ac.uk/Profiles/InfectDis/Parish%20Tanya.htm)

Tanya has edited five books on mycobacteria and published numerous papers on the basic biology and genetics of M. tuberculosis. She is an Editor of Microbiology (UK), and a member of the Acid Fast Club (http://www.nibsc.ac.uk/partners/afc/) for which she previously served as the (Hon) Secretary.

 

Recent Publications:

  • Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using  optimized far-red reporters. 2010. P. Carroll, L.J. Schreuder, J. Muwanguzi-Karugaba, S. Wiles, B. D. Robertson, J. Ripoll, T. H. Ward, G. J. Bancroft, U. E. Schaible, and T. Parish. PLoS One. Mar 23;5(3):e9823.
  • The EmbC arabinosyltransferase is inhibited by ethambutol in Mycobacterium tuberculosis. 2009. R. Goude and T. Parish. Antimicrob. Ag. Chemother. 53: 4138-4146.
  • The genetics of cell wall biosynthesis. R. Goude and T. Parish. Future Microbiology. 2008. 3: 299-313.
  • Fosmidomycin resistance in Mycobacterium tuberculosis is due to a lack of uptake. A.C. Brown and T. Parish. BMC Microbiology. 8:78.
  • EmbC plays a critical role in Mycobacterium tuberculosis. R. Goude, A.G. Amin, D. Chatterjee and T. Parish. J. Bacteriol. 190: 4335­-4341.
  • Mycobacteria Protocols. Second Edition. Eds A.C. Brown and T. Parish. 2008.
  • Mycobacterium: Genetics and Molecular Biology. Eds A.C. Brown and T. Parish. 2009.