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Leprosy Diagnostics
The Challenge
Current leprosy control strategies are based upon prompt detection and treatment. However, it is estimated that the delay from the time of onset of the first discernible symptom to clinical diagnosis is anywhere from 1-3 years in more than half of all leprosy patients. In countries where leprosy is extremely rare, patients are often misdiagnosed and mistreated before eventually being properly identified. Such delays can have a dramatic impact on the degree of nerve function impairment and response to treatment.
Our Solutions
Leprosy requires better diagnostic and prognostic tools to accompany new strategies aimed at further reducing global and regional burdens. As part of our overall leprosy program, and in collaboration with industrial partners, we are developing both rapid diagnostic tests for primary leprosy diagnosis and new tools for the objective assessment of treatment.
Publications
Duthie MS, Truman RW, Goto W, O'Donnell J, Hay MN, Spencer JS, Carter D, Reed SG. 2011. Insight toward Early Diagnosis of Leprosy through Analysis of the Developing Antibody Responses of Mycobacterium leprae-Infected Armadillos. Clin Vaccine Immunol 18: 254-9
Duthie MS, Hay MN, Morales CZ, Carter L, Mohamath R, Ito L, Oyafuso LK, Manini MI, Balagon MV, Tan EV, Saunderson PR, Reed SG, Carter D. 2010. Rational design and evaluation of a multiepitope chimeric fusion protein with the potential for leprosy diagnosis. Clin Vaccine Immunol 17: 298-303
Duthie MS, Ireton GC, Kanaujia GV, Goto W, Liang H, Bhatia A, Busceti JM, Macdonald M, Neupane KD, Ranjit C, Sapkota BR, Balagon M, Esfandiari J, Carter D, Reed SG. 2008. Selection of antigens and development of prototype tests for point-of-care leprosy diagnosis. Clin Vaccine Immunol 15: 1590-7
Key Scientist
Malcolm S. Duthie
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