Infectious Disease Research Institute

Authors: Christopher B. Fox, Ryan M. Kramer, Lucien Barnes V, Quinton M. Dowling, and Thomas S. Vedvick

Journal: Therapeutic Advances in Vaccines

Publication Date: May, 2013

Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania

Authors: Fox CB, Huynh C, O'Hara MK, Onu A.

Journal: Vaccine

Publication Date: March, 2013

Adjuvanted pandemic influenza vaccine: variation of emulsion components affects stability, antigen structure, and vaccine efficacy

Authors: Fox CB, Barnes V L, Evers T, Chesko JD, Vedvick TS, Coler RN, Reed SG, Baldwin SL.

Journal: Influenze and other respiratory diseases

Publication Date: November, 2012

Effects on immunogenicity by formulations of emulsion-based adjuvants for malaria vaccines

Authors: Fox CB, Baldwin SL, Vedvick TS, Angov E, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: October, 2012

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140

Authors: Arias MA, Van Roey GA, Tregoning JS, Moutaftsi M, Coler RN, Windish HP, Reed SG, Carter D, Shattock RJ.

Journal: PLoS One

Publication Date: July, 2012

Adjuvants for human vaccines

Authors: Alving CR, Peachman KK, Rao M, Reed SG.

Journal: Current Opinion in Immunology

Publication Date: June, 2012

Intradermally administered TLR4 agonist GLA-SE enhances the capacity of human skin DCs to activate T cells and promotes emigration of Langerhans cells

Authors: Schneider LP, Schoonderwoerd AJ, Moutaftsi M, Howard RF, Reed SG, de Jong EC, Teunissen MB.

Journal: Vaccine

Publication Date: June, 2012

Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice

Authors: Lumsden JM, Nurmukhambetova S, Klein JH, Sattabongkot J, Bennett JW, Bertholet S, Fox CB, Reed SG, Ockenhouse CF, Howard RF, Polhemus ME, Yadava A.

Journal: Vaccine

Publication Date: May, 2012

Emulsion-based Vaccine Adjuvants

Authors: Christopher B Fox , Darrick Carter & Steven G Reed

Journal: Book; Doi: 10.2217/ebo.11.371

Publication Date: March, 2012

Immunomodulatory and Physical Effects of Phospholipid Composition in Vaccine Adjuvant Emulsions

Authors: Fox CB, Baldwin SL, Duthie MS, Reed SG, Vedvick TS.

Journal: AAPS PharmSciTech.

Publication Date: March, 2012

A TLR4 agonist synergizes with dendritic cell-directed lentiviral vectors for inducing antigen-specific immune responses

Authors: Xiao L, Kim J, Lim M, Dai B, Yang L, Reed SG, Baltimore D, Wang P.

Journal: Vaccine

Publication Date: March, 2012

GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults

Authors: Behzad H, Huckriede AL, Haynes L, Gentleman B, Coyle K, Wilschut JC, Kollmann TR, Reed SG, McElhaney JE.

Journal: The Journal of Infectious Diseases

Publication Date: February, 2012

Use of defined TLR ligands as adjuvants within human vaccines

Authors: Duthie MS, Windish HP, Fox CB, Reed SG.

Journal: Immunological Reviews

Publication Date: January, 2012

Transcriptional profiling of TLR-4/7/8-stimulated guinea pig

Authors: Ching LK, Mompoint F, Guderian JA, Picone A, Orme IM, Coler RN, Reed SG, Baldwin SL.

Journal: Journal of Immunological Methods

Publication Date: January, 2012

Effects of Emulsifier Concentration, Composition, and Order of Addition in Squalenephosphatidylcholine Oil-in-Water Emulsions

Authors: Fox CB, Lin S, Sivananthan SJ, Dutill TS, Forseth KT, Reed SG, Vedvick TS.

Journal: Pharmaceutical Development and Technology

Publication Date: January, 2012

Immunomodulatory and Physical Effects of Oil Composition in Vaccine Adjuvant

Authors: Fox CB, Baldwin SL, Duthie MS, Reed SG. Vedvick TS.

Journal: Vaccine

Publication Date: November, 2011

Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions

Authors: Baldwin SL, Fox CB, Pallansch MA, Coler RN, Reed SG, Friede M.

Journal: Vaccine

Publication Date: January, 2011

Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants

Authors: Fox CB, Friede M, Reed SG, Ireton GC.

Journal: Sub-cellular Biochemistry

Publication Date: December, 2010

A synthetic adjuvant to enhance and expand immunes165 HT responses to influenza vaccines

Authors: Coler RN, Baldwin SL, Shaverdian N, Bertholet S, Reed SJ, Raman VS, Lu X, DeVos J, Hancock K, Katz JM, Vedvick TS, Duthie MS, Clegg CH, Van Hoeven N, Reed SG.

Journal: PLoS One

Publication Date: December, 2010

Characterization of Aluminum Hydroxide Gel and Oil-in-Water Emulsion Formulations Containing CpG ODNs

Authors: Fox CB, Dutill TS, Chesko J, Anderson RC, Reed SG, Vedvick TS.

Journal: BioPharm International

Publication Date: October, 2010

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

Authors: Rhea N. Coler, Sylvie Bertholet, Magdalini Moutaftsi, Jeff A. Guderian, Hillarie Plessner Windish, Susan L. Baldwin, Elsa M. Laughlin, Malcolm S. Duthie, Christopher B. Fox, Darrick Carter, Martin Friede, Thomas S. Vedvick, Steven G. Reed

Journal: PLoS One

Publication Date: September, 2010

Role of Adjuvants in Modeling the Immune Response

Authors: Carter D, Reed SG.

Journal: Current Opinion in HIV and AIDS

Publication Date: September, 2010

Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations

Authors: Anderson RC, Fox CB, Dutill TS, Shaverdian N, Evers TL, Poshusta GR, Chesko J, Coler RN, Friede M, Reed SG, Vedvick TS.

Journal: Colloids and Surfaces. B, Biointerfaces

Publication Date: January, 2010

Protection against intestinal amebiasis by a recombinant vaccine is transferrable by T cells and mediated by gamma interferon

Authors: Guo X, Barroso L, Becker SM, Lyerly DM, Vedvick TS, Reed SG, Petri WA Jr, Houpt ER.

Journal: Infection and Immunity

Publication Date: June, 2009

New horizons in adjuvants for vaccine development

Authors: Reed SG, Bertholet S, Coler RN, Friede M.

Journal: Trends in Immunology

Publication Date: January, 2009

Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions

Authors: Fox CB, Anderson RC, Dutill TS, Goto Y, Reed SG, Vedvick TS.

Journal: Colloids and Surfaces. B, Biointerfaces

Publication Date: December, 2008

Taking toll: lipid A mimetics as adjuvants and immunomodulators

Authors: Persing DH, Coler RN, Lacy MJ, Johnson DA, Baldridge JR, Hershberg RM, Reed SG.

Journal: Trends in Microbiology

Publication Date: December, 2002

Chagas Disease

Lateral flow immunoassay for diagnosis of Trypansoma cruzi infection with high correlation to the radioimmunoprecipitation assay

Authors: Houghton RL, Stevens YY, Hjerrild K, Guderian J, Okamoto M, Kabir M, Reed SG, Leiby DA, Morrow WJ, Lorca M, Raychaudhuri S.

Journal: Clinical and Vaccine Immunology

Publication Date: April, 2009

Immunological dominance of Trypanosoma cruzi tandem repeat proteins

Authors: Goto Y, Carter D, Reed SG.

Journal: Infection and Immunity

Publication Date: September, 2008

Parasite-induced chronic inflammation is not exacerbated by immunotherapy before or during Trypanosoma cruzi Infection

Authors: Duthie MS, Kahn M, Zakayan A, White M, Kahn SJ.

Journal: Clinical and Vaccine Immunology

Publication Date: August, 2007

During acute Trypanosoma cruzi infection highly susceptible mice deficient in natural killer cells are protected by a single alpha-galactosylceramide treatment

Authors: Duthie MS, Kahn SJ.

Journal: Immunology

Publication Date: November, 2006

NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection

Authors: Duthie MS, Kahn SJ.

Journal: International Immunology

Publication Date: May, 2005

Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection

Authors: Duthie MS, Kahn M, White M, Kapur RP, Kahn SJ.

Journal: Infection and Immunity

Publication Date: March, 2005

Trypanosoma cruzi-infected individuals demonstrate varied antibody responses to a panel of trans-sialidase proteins encoded by SA85-1 genes

Authors: Duthie MS, Cetron MS, Van Voorhis WC, Kahn SJ.

Journal: Acta Tropica

Publication Date: March, 2005

Critical proinflammatory and anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during Trypanosoma cruzi infection

Authors: Duthie MS, Kahn M, White M, Kapur RP, Kahn SJ.

Journal: Infection and Immunity

Publication Date: January, 2005

Cloning and characterization of a gene encoding an immunoglobulin-binding receptor on the cell surface of some members of the family trypanosomatidae

Authors: Campos-Neto A, Suffia I, Cavassani KA, Jen S, Greeson K, Ovendale P, Silva JS, Reed SG, Skeiky YA.

Journal: Infection and Immunity

Publication Date: September, 2003

Treatment with alpha-galactosylceramide before Trypanosoma cruzi infection provides protection or induces failure to thrive

Authors: Duthie MS, Kahn SJ.

Journal: Journal of Immunology

Publication Date: June, 2002

LemEnzyme-linked immunosorbent assay for serological diagnosis of Chagas' Disease employing a Trypanosoma cruzi recombinant antigen that consists of four different peptides

Authors: Ferreira AW, Belem ZR, Lemos EA, Reed SG, Campos-Neto A.

Journal: Journal of Clinical Microbiology

Publication Date: December, 2001

Immunology of Trypanosoma cruzi infections

Authors: Reed, S.G.

Journal: In Book: Chemical Immunology, Immunology of Intracellular Parasitism. 70:124-143.

Publication Date: January, 1998

Molecular cloning and characterization of two iron superoxide dismutase cDNAs from Trypanosoma cruzi

Authors: Ismail SO, Paramchuk W, Skeiky YA, Reed SG, Bhatia A, Gedamu L.

Journal: Molecular and Biochemical Parasitology

Publication Date: June, 1997

Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin-10: Role of NK cells

Authors: Cardillo F, Voltarelli JC, Reed SG, Silva JS.

Journal: Infection and Immunity

Publication Date: January, 1996

Interleukin-10 mediates susceptibility to Trypanosoma cruzi infection.

Authors: Reed SG, Brownell CE, Russo DM, Silva JS, Grabstein KH, Morrissey PJ.

Journal: Journal of Immunology

Publication Date: October, 1994

Chlamydia

Identification and characterization of novel recombinant vaccine antigens for immunization against genital Chlamydia trachomatis

Authors: Coler RN, Bhatia A, Maisonneuve JF, Probst P, Barth B, Ovendale P, Fang H, Alderson M, Lobet Y, Cohen J, Mettens P, Reed SG.

Journal: FEMS Immunology and Medical Microbiology

Publication Date: December, 2009

Influenza

Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania

Authors: Fox CB, Huynh C, O'Hara MK, Onu A.

Journal: Vaccine

Publication Date: October, 2012

Enhanced humoral and type 1 immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion

Authors: Baldwin SL, Shaverdian N, Goto Y, Duthie MS, Raman VS, Evers T, Mompoint F, Vedvick TS, Bertholet S, Coler RN, Reed SG.

Journal: Vaccine

Publication Date: December, 2009

Leishmaniasis

Case study for a vaccine against leishmaniasis

Authors: Alvar J, Croft SL, Kaye P, Khamesipour A, Sundar S, Reed SG.

Journal: Vaccine

Publication Date: April, 2013

Adjuvants for Leishmania vaccines: from models to clinical application

Authors: Raman VS, Duthie MS, Fox CB, Matlashewski G, Reed SG.

Journal: Frontiers in Immunology

Publication Date: June, 2012

KSAC, the First Defined Polyprotein Vaccine Candidate for Visceral Leishmaniasis

Authors: Goto Y, Bhatia A, Raman VS, Liang H, Mohamath R, Picone AF, Vidal SE, Vedvick TS, Howard RF, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: January, 2012

Application of an improved enzyme-linked immunosorbent assay method for serological diagnosis of canine leishmaniasis

Authors: Santarem N, Silvestre R, Cardoso L, Schallig H, Reed SG, Cordeiro-da-Silva A.

Journal: Journal of Clinical Microbiology

Publication Date: January, 2012

Distinct antigen recognition patterns during zoonotic visceral leishmaniasis in humans and dogs

Authors: Goto Y, Howard RF, Bhatia A, Trigo J, Nakatani M, Netto EM, Reed SG.

Journal: Veterinary Parasitology

Publication Date: January, 2012

Second-generation vaccines against leishmaniasis

Authors: Coler RN, Reed SG.

Journal: Trends in Parasitology

Publication Date: January, 2012

Evaluation of rK28 antigen for serodiagnosis of visceral Leishmaniasis in India

Authors: Vaish M, Bhatia A, Reed SG, Chakravarty J, Sundar S.

Journal: Clinical Microbiology and Infection: The Official Journal of the European Society of Clinical Microbiology and Infectious Diseases

Publication Date: January, 2012

The development and clinical evaluation of second-generation leishmaniasis vaccines

Authors: Duthie MS, Raman VS, Piazza FM, Reed SG.

Journal: Vaccine

Publication Date: November, 2011

A clinical trial to evaluate the safety and immunogenicity of the LEISHF1+MPL-SE vaccine for use in the prevention of visceral leishmaniasis

Authors: Chakravarty J, Kumar S, Trivedi S, Rai VK, Singh A, Ashman JA, Laughlin EM, Coler RN, Kahn SJ, Beckmann AM, Cowgill KD, Reed SG, Sundar S, Piazza FM.

Journal: Vaccine

Publication Date: March, 2011

A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1 + MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis

Authors: Llanos-Cuentas A, Calderon W, Cruz M, Ashman JA, Alves FP, Coler RN, Bogatzki LY, Bertholet S, Laughlin EM, Kahn SJ, Beckmann AM, Cowgill KD, Reed SG, Piazza FM.

Journal: Vaccine

Publication Date: October, 2010

Design, Development and Evaluation of rK28-based point-of-care tests for improving rapid diagnosis of visceral leishmaniasis

Authors: Pattabhi S, Whittle J, Mohamath R, El-Safi S, Moulton GG, Guderian JA, Colombara D, Abdoon AO, Mukhtar MM, Mondal D, Esfandiari J, Kumar S, Chun P, Reed SG, Bhatia A.

Journal: PLoS Neglected Tropical Diseases

Publication Date: September, 2010

Antigen discovery for serological diagnosis of visceral leishmaniasis

Authors: Goto Y, Reed S.

Journal: Current Chemical Biology

Publication Date: September, 2010

Applying TLR synergy in immunotherapy: implications in cutaneous leishmaniasis

Authors: Raman VS, Bhatia A, Picone A, Whittle J, Bailor HR, O'Donnell J, Pattabhi S, Guderian JA, Mohamath R, Duthie MS, Reed SG.

Journal: Journal of Immunology

Publication Date: August, 2010

A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1 + MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis

Authors: Nascimento E, Fernandes DF, Vieira EP, Campos-Neto A, Ashman JA, Alves FP, Coler RN, Bogatzki LY, Kahn SJ, Beckmann AM, Pine SO, Cowgill KD, Reed SG, Piazza FM.

Journal: Vaccine

Publication Date: August, 2010

Evaluation of ex vivo human immune response against candidate antigens for a visceral leishmaniasis vaccine

Authors: Kumar R, Goto Y, Gidwani K, Cowgill KD, Sundar S, Reed SG.

Journal: American Journal of Tropical Medicine and Hygiene

Publication Date: May, 2010

Upregulated expression of B-cell antigen family tandem repeat proteins by Leishmania amastigotes

Authors: Goto Y, Carter D, Guderian J, Inoue N, Kawazu S, Reed SG.

Journal: Infection and Immunity

Publication Date: May, 2010

Treatment of canine visceral leishmaniasis by the vaccine Leish-111f+MPL-SE

Authors: Trigo J, Abbehusen M, Netto EM, Nakatani M, Pedral-Sampaio G, de Jesus RS, Goto Y, Guderian J, Howard RF, Reed SG.

Journal: Vaccine

Publication Date: April, 2010

Safety and immunogeneicity of a defined vaccine for the prevention of cutaneous leishmaniasis

Authors: Vélez ID, Gilchrist K, Martínez S, Ramírez-Pineda JR, Ashman JA, Alves FP, Coler RN, Bogatzki LY, Kahn SJ, Beckmann AM, Cowgill KD, Reed SG, Piazza FM.

Journal: Vaccine

Publication Date: December, 2009

Optimized subunit vaccine protects against experimental leishmaniasis

Authors: Bertholet S, Goto Y, Carter L, Bhatia A, Howard RF, Carter D, Coler RN, Vedvick TS, Reed SG.

Journal: Vaccine

Publication Date: November, 2009

Leishmania infantum sterol 24-c-methyltransferase formulated with MPL-SE induces cross-protection against L. major infection

Authors: Goto Y, Bhatia A, Raman VS, Vidal SE, Bertholet S, Coler RN, Howard RF, Reed SG.

Journal: Vaccine

Publication Date: May, 2009

Real-Time In Vivo Green Fluorescent Protein Imaging of a Murine Leishmaniasis Model as a New Tool for Leishmania Vaccines and Drug Discovery

Authors: Mehta SR, Huang R, Yang M, Zhang XQ, Kolli B, Chang KP, Hoffman RM, Goto Y, Badaro R, Schooley RT.

Journal: Clinical and Vaccine Immunology

Publication Date: October, 2008

Evaluation of an immunochemotherapeutic Q1 protocol constituted of N-methyl meglumine antimoniate (Glucantime®) and the recombinant Leish-110f® + MPL-SE® vaccine to treat canine visceral leishmaniasis.

Authors: Miret J, Nascimento E, Sampaio W, França JC, Fujiwara RT, Vale A, Dias ES, Vieira E, da Costa RT, Mayrink W, Campos Neto A, Reed S.

Journal: Vaccine

Publication Date: March, 2008

An improved manufacturing process for a recombinant polyprotein vaccine

Authors: Vedvick, T.S., Carter L., Moulton, G., Goto, Y., Bertholet, S., Reed S.G., Carter, D.

Journal: BioPharm International

Publication Date: January, 2008

Protective immunization against visceral leishmaniasis using Leishmania sterol 24-c-methyltransferase formulated in adjuvant

Authors: Goto Y, Bogatzki LY, Bertholet S, Coler RN, Reed SG.

Journal: Vaccine

Publication Date: October, 2007

Leish-111f, a recombinant polyprotein vaccine that protects against visceral leishmaniasis by elicitation of CD4+ T cells

Authors: Coler RN, Goto Y, Bogatzki L, Raman V, Reed SG.

Journal: Infectious Immunology

Publication Date: September, 2007

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

Authors: Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, Flynn BJ, Hoff ST, Andersen P, Reed SG, Morris SL, Roederer M, Seder RA.

Journal: Nature Medicine

Publication Date: July, 2007

Bioinformatic identification of tandem repeat antigens of the Leishmania donovani complex

Authors: Goto Y, Coler RN, Reed SG.

Journal: Infection and Immunity

Publication Date: February, 2007

Immunotherapy for Drug Refractory Mucosal Leishmaniasis

Authors: Badaro R, Lobo I, Munos A, Netto EM, Modabber F, Campos-Neto A, Coler RN, Reed SG.

Journal: Journal of Infectious Diseases

Publication Date: September, 2006

Cloning, characterization, and serodiagnostic evaluation of Leishmania infantum tandem repeat proteins

Authors: Goto Y, Coler RN, Guderian J, Mohamath R, Reed SG.

Journal: Infection and Immunity

Publication Date: July, 2006

Immunogenicity in dogs of three recombinant antigens (TSA, LeIF and LmSTI1) potential vaccine candidates for canine visceral leishmaniasis

Authors: Fujiwara RT, Vale AM, França da Silva JC, da Costa RT, Quetz Jda S, Martins Filho OA, Reis AB, Corrêa Oliveira R, Machado-Coelho GL, Bueno LL, Bethony JM, Frank G, Nascimento E, Genaro O, Mayrink W, Reed S, Campos-Neto A.

Journal: Veterinary Research

Publication Date: September, 2005

Development of a leishmaniasis vaccine: the importance of MPL

Authors: Reed SG, Coler RN, Campos-Neto A.

Journal: Expert Review of Vaccines

Publication Date: April, 2003

Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity

Authors: Chang KP, Reed SG, McGwire BS, Soong L.

Journal: Acta Tropica

Publication Date: March, 2003

Epidemiological and immunological aspects of human visceral leishmaniasis on Margarita Island, Venezuela

Authors: Zerpa O, Ulrich M, Benitez M, Avila C, Rodríguez V, Centeno M, Belizario D, Reed SG, Convit J.

Journal: Memorias do Instituto Oswaldo Cruz.

Publication Date: December, 2002

The sensitivity and specificity of Leishmania chagasi recombinant k39 antigen in the diagnosis of American visceral leishmaniasis and in differentiating active from subclinical infection

Authors: Braz RF, Nascimento ET, Martins DR, Wilson ME, Pearson RD, Reed SG, Jeronimo SM.

Journal: American Journal of Tropical Medicine and Hygiene

Publication Date: October, 2002

Protective efficacy of a tandemlytml linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL® adjuvant

Authors: Skeiky YA, Coler RN, Brannon M, Stromberg E, Greeson K, Crane RT, Webb JR, Campos-Neto A, Reed SG.

Journal: Vaccine

Publication Date: September, 2002

Immunization with a polyprotein vaccine consisting of the T-Cell antigens thiol-specific antioxidant, Leishmania major stress-inducible protein 1, and Leishmania elongation initiation factor protects against leishmaniasis

Authors: Coler RN, Skeiky YA, Bernards K, Greeson K, Carter D, Cornellison CD, Modabber F, Campos-Neto A, Reed SG.

Journal: Infection and Immunity

Publication Date: August, 2002

Vaccination with plasmid DNA encoding TSA/LmSTI1 leishmanial fusion proteins confers protection against Leishmania major infection in susceptible BALB/c mice

Authors: Campos-Neto A, Webb JR, Greeson K, Coler RN, Skeiky YA, Reed SG.

Journal: Infection and Immunity

Publication Date: June, 2002

Potent Stimulation of the innate immune system by a Leishmania brasiliensis recombinant protein

Authors: Borges MM, Campos-Neto A, Sleath P, Grabstein KH, Morrissey PJ, Skeiky YA, Reed SG.

Journal: Infection and Immunity

Publication Date: September, 2001

Leishmaniasis vaccination: targeting the source of infection

Authors: Reed SG.

Journal: Journal of Experimental Medicine

Publication Date: August, 2001

Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primated in models of human disease

Authors: Campos-Neto A, Porrozzi R, Greeson K, Coler RN, Webb JR, Seiky YA, Reed SG, Grimaldi G Jr.

Journal: Infection and Immunity

Publication Date: June, 2001

The potency and durability of dna- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge

Authors: Méndez S, Gurunathan S, Kamhawi S, Belkaid Y, Moga MA, Skeiky YA, Campos-Neto A, Reed S, Seder RA, Sacks D.

Journal: Journal of Immunology

Publication Date: April, 2001

Identification and characterization of T cell stimulating antigens from Leishmania by CD4 T cell expression cloning

Authors: Probst P, Stromberg E, Ghalib HW, Mozel M, Badaro R, Reed SG, Webb JR.

Journal: Journal of Immunology

Publication Date: January, 2001

Circulating levels of sTNFR and discrepancy between cytotoxicity and immnoreactivity of TNF-á in patients with visceral leishmaniasis

Authors: Medeiros IM, Reed S, Castelo A, Salomão R.

Journal: Clinical Microbiology and Infection

Publication Date: January, 2000

LeIF: A recombinant Leishmania protein that induces an IL-12 mediated Th1 cytokine profile

Authors: Skeiky YA, Kennedy M, Kaufman D, Borges MM, Guderian JA, Scholler JK, Ovendale PJ, Picha KS, Morrissey PJ, Grabstein KH, Campos-Neto A, Reed SG.

Journal: Journal of Immunology

Publication Date: December, 1998

Serodiagnosis and epidemiology of visceral leishmaniasis in Turkey

Authors: Ozensoy S, Ozbel Y, Turgay N, Alkan MZ, Gul K, Gilman-Sachs A, Chang KP, Reed SG, Ozcel MA.

Journal: The American Journal of Tropical Medicine and Hygiene

Publication Date: September, 1998

Human and murine immune responses to a novel Leishmania major recombinant protein encoded by a multi-copy gene family

Authors: Webb JR, Campos-Neto A, Ovendale PJ, Martin TI, Stromberg EJ, Badaro R, Reed SG.

Journal: Infection and Immunity

Publication Date: July, 1998

Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis

Authors: Skeiky YA, Benson DR, Costa JL, Badaro R, Reed SG.

Journal: Infection and Immunity

Publication Date: December, 1997

Molecular characterization of the heat-inducible LmSTI1 protein of Leishmania major

Authors: Webb JR, Campos-Neto A, Skeiky YA, Reed SG.

Journal: Molecular and Biochemical Parasitology

Publication Date: November, 1997

A Leishmania protein that modulates interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production and expression of B7-1 in human monocyte-derived antigen-presenting cells

Authors: Probst P, Skeiky YA, Steeves M, Gervassi A, Grabstein KH, Reed SG.

Journal: European Journal of Immunology

Publication Date: October, 1997

Circulating T Helper 1 (Th1) cell- and Th2 cell-associated cytokines in Indian patients with visceral leishmaniasis

Authors: Sundar S, Reed SG, Sharma S, Mehrotra A, Murray HW.

Journal: American Journal of Tropical Medicine and Hygiene

Publication Date: May, 1997

Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis

Authors: Webb JR, Kaufmann D, Campos-Neto A, Reed SG.

Journal: Journal of Immunology

Publication Date: December, 1996

rK39: A cloned antigen of Leishmania chagasi that both detects and predicts active visceral leishmaniasis

Authors: R. Badaro, D. Benson, M. C. Eulalio, M. Freire, S. Cunha, E. M. Netto, D. Pedral-Sampaio, C. Madureira, J. M. Burns, R. L. Houghton, J. R. David and S. G. Reed

Journal: The Journal of Infectious Diseases

Publication Date: March, 1996

CD40 ligand is required to generate a protective cell-mediated immune response to Leishmania major

Authors: Campbell KA, Ovendale PJ, Kennedy MK, Fanslow WC, Reed SG, Maliszewski CR.

Journal: Immunity

Publication Date: March, 1996

Diagnostic and prognostic value of rK39 antigen in Indian leishmaniasis

Authors: Singh S, Gilman-Sachs A, Chang KP, Reed SG.

Journal: The Journal of Parasitology

Publication Date: December, 1995

Cloning and expression of a Leishmania donovani gene instructed by a peptide isolated from major histocompatibility complex class II molecules of infected macrophagesrom

Authors: Campos-Neto A, Soong L, Cordova JL, Sant'Angelo D, Skeiky YA, Ruddle NH, Reed SG, Janeway C Jr, McMahon-Pratt D.

Journal: Journal of Experimental Medicine

Publication Date: November, 1995

Immune responses of leishmaniasis patients to Leishmania and human heat shock proteins

Authors: Skeiky YA, Benson DR, Guderian JA, Whittle JA, Bacelar O, Carvalho EM, Reed SG.

Journal: Infection and Immunity

Publication Date: October, 1995

Characterization of a Leishmania tropica antigen that detects immune responses in Desert Storm viscerotropic leishmaniasis patients

Authors: Dillon DC, Day CH, Whittle JA, Magill AJ, Reed SG.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Publication Date: August, 1995

IL-12 enhances Th1 type responses in human Leishmania donovani infections

Authors: Ghalib HW, Whittle JA, Kubin M, Hashim FA, el-Hassan AM, Grabstein KH, Trinchieri G, Reed SG.

Journal: Journal of Immunology

Publication Date: May, 1995

A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin-12

Authors: Skeiky YA, Guderian JA, Benson DR, Bacelar O, Carvalho EM, Kubin M, Badaro R, Trinchieri G, Reed SG.

Journal: The Journal of Experimental Medicine

Publication Date: April, 1995

Visceral leishmaniasis in a new ecological niche near a major metropolitan area of Brazil

Authors: Cunha S, Freire M, Eulalio C, Critosvao J, Netto E, Johnson WD Jr, Reed SG, Badaro R.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene

Publication Date: March, 1995

Leprosy

Development and pre-clinical assessment of a 73kD chimeric fusion protein as a defined sub-unit vaccine for leprosy

Authors: Duthie MS, Sampaio LH, Oliveira RM, Raman VS, O'Donnell J, Bailor HR, Ireton GC, Sousa AL, Stefani MM, Reed SG.

Journal: Vaccine

Publication Date: January, 2013

Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I

Authors: Qiong-Hua P, Zhong-Yi Z, Jun Y, Yan W, Lian-Chao Y, Huan-Ying L, Reed SG, Duthie MS.

Journal: Journal of Tropical Medicine

Publication Date: January, 2013

Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy.

Authors: Spencer JS, Duthie MS, Geluk A, Balagon MF, Kim HJ, Wheat WH, Chatterjee D, Jackson M, Li W, Kurihara JN, Maghanoy A, Mallari I, Saunderson P, Brennan PJ, Dockrell HM.

Journal: Memorias do Instituto Oswaldo Cruz

Publication Date: December, 2012

Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil

Authors: Hungria EM, Oliveira RM, Souza AL, Costa MB, Souza VN, Silva EA, Moreno FR, Nogueira ME, Costa MR, Silva SM, Bührer-Sékula S, Reed SG, Duthie MS, Stefani MM.

Journal: Memorias do Instituto Oswaldo Cruz

Publication Date: December, 2012

The potential for vaccination in leprosy elimination: new tools for targeted interventions

Authors: Duthie MS, Saunderson P, Reed SG.

Journal: Memorias do Instituto Oswaldo Cruz

Publication Date: December, 2012

Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil

Authors: Hungria EM, de Oliveira RM, de Souza AL, Costa MB, de Souza VN, Silva EA, Moreno FR, Nogueira ME, Costa MR, Silva SM, Bührer-Sékula S, Reed SG, Duthie MS, Stefani MM.

Journal: Memorias do Instituto Oswaldo Cruz

Publication Date: December, 2012

Serologic follow-up of IgG responses against recombinant mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela

Authors: Rada E, Duthie MS, Reed SG, Aranzazu N, Convit J.

Journal: Memorias do Instituto Oswaldo Cruz

Publication Date: December, 2012

Neurological disability in leprosy: incidence and gender association in Sergipe, Brazil

Authors: de Oliveira DT, Bezerra MM, de Almeida JA, Duthie M, Reed S, de Jesus AR.

Journal: Geospatial Health

Publication Date: September, 2012

Advances and hurdles on the way toward a leprosy vaccine

Authors: Duthie MS, Gillis TP, Reed SG.

Journal: Human Vaccines

Publication Date: November, 2011

Evaluation of various cytokines elicited during antigen-specific recall as potential risk indicators for the differential development of leprosy

Authors: Sampaio LH, Sousa AL, Barcelos MC, Reed SG, Stefani MM, Duthie MS.

Journal: European Journal of Clinical Microbiology & Infectious Diseases

Publication Date: October, 2011

Specific IgG antibody responses may be used to monitor leprosy treatment efficacy and as a recurrence prognostic markers

Authors: Duthie MS, Hay MN, Rada EM, Convit J, Ito L, Oyafuso LK, Manini MI, Goulart IM, Lobato J, Goulart LR, Carter D, Reed SG.

Journal: European Journal of Clinical Microbiology and Infectious Diseases

Publication Date: October, 2011

Clinical, Immunological, and genetic aspects in leprosy

Authors: Simon, M; Scherlock, J; Duthie, MS, de Jesus, AR.

Journal: Drug Development Research

Publication Date: September, 2011

Insight toward early diagnosis of leprosy through analysis of the developing antibody responses of Mycobacterium leprae-infected armadillos

Authors: Duthie MS, Truman RW, Goto W, O'Donnell J, Hay MN, Spencer JS, Carter D, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: February, 2011

Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development

Authors: Sampaio LH, Stefani MM, Oliveira RM, Sousa AL, Ireton GC, Reed SG, Duthie MS.

Journal: BMC Infectious Diseases

Publication Date: January, 2011

Rational design and evaluation of a multiepitope chimeric fusion protein and the potential for leprosy diagnosis

Authors: Duthie MS, Hay MN, Morales CZ, Carter L, Mohamath R, Ito L, Oyafuso LK, Manini MI, Balagon MV, Tan EV, Saunderson PR, Reed SG, Carter D.

Journal: Clinical and Vaccine Immunology

Publication Date: February, 2010

Rational design and evaluation of a multiepitope chimeric fusion protein and the potential for leprosy diagnosis

Authors: Duthie MS, Hay MN, Morales CZ, Carter L, Mohamath R, Ito L, Oyafuso LK, Manini MI, Balagon MV, Tan EV, Saunderson PR, Reed SG, Carter D.

Journal: Clinical and Vaccine Immuniology

Publication Date: February, 2010

Vaccination with the ML0276 antigen reduces local inflammation but not bacterial burden during experimental Mycobacterium leprae infection

Authors: Raman VS, ODonnell J, Bailor HR, Goto W, Lahiri R, Gillis TP, Reed SG, Duthie MS

Journal: Infection and Immunity

Publication Date: December, 2009

Antigen-specific T-cell responses of leprosy patients

Authors: Duthie MS, Goto W, Ireton GC, Reece ST, Sampaio LH, Grassi AB, Sousa AL, Martelli CM, Stefani MM, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: November, 2008

Selection of antigens and development of prototype tests for point-of-care leprosy diagnosis

Authors: Duthie MS, Ireton GC, Kanaujia GV, Goto W, Liang H, Bhatia A, Busceti JM, Macdonald M, Neupane KD, Ranjit C, Sapkota BR, Balagon M, Esfandiari J, Carter D, Reed SG

Journal: Clinical and Vaccine Immunology

Publication Date: October, 2008

Use of protein antigens for early serological diagnosis of leprosy

Authors: Duthie MS, Goto W, Ireton GC, Reece ST, Cardoso LP, Martelli CM, Stefani MM, Nakatani M, de Jesus RC, Netto EM, Balagon MV, Tan E, Gelber RH, Maeda Y, Makino M, Hoft D, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: November, 2007

Antigen-specific cellular and humoral responses are induced by intradermal Mycobacterium leprae infection of the mouse ear

Authors: Duthie MS, Reece ST, Lahiri R, Goto W, Raman VS, Kaplan J, Ireton GC, Bertholet S, Gillis TP, Krahenbuhl JL, Reed SG.

Journal: Infection and Immunity

Publication Date: November, 2007

ML0405 and ML2331 are antigens of Mycobacterium leprae with potential for diagnosis of leprosy

Authors: Reece ST, Ireton G, Mohamath R, Guderian J, Goto W, Gelber R, Groathouse N, Spencer J, Brennan P, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: March, 2006

Malaria

Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice

Authors: Lumsden JM, Nurmukhambetova S, Klein JH, Sattabongkot J, Bennett JW, Bertholet S, Fox CB, Reed SG, Ockenhouse CF, Howard RF, Polhemus ME, Yadava A.

Journal: Vaccine

Publication Date: May, 2012

Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic toll-like receptor 4 agonist formulated in an emulsion

Authors: Lumsden JM, Pichyangkul S, Srichairatanakul U, Yongvanitchit K, Limsalakpetch A, Nurmukhambetova S, Klein J, Bertholet S, Vedvick TS, Reed SG, Sattabongkot J, Bennett JW, Polhemus ME, Ockenhouse CF, Howard RF, Yadava A.

Journal: Infection and Immunity

Publication Date: September, 2011

Targeting TLRs expands the antibody repertoire in response to a malaria vaccine

Authors: Wiley SR, Raman VS, Desbien A, Bailor HR, Bhardwaj R, Shakri AR, Reed SG, Chitnis CE, Carter D.

Journal: Science Translational Medicine

Publication Date: July, 2011

A synthetic agonist formulated in an emulsion enhances humoral and Type 1 cellular immune responses against GMZ2 - A GLURP - MSP3 fusion protein malaria vaccine candidate

Authors: Lousada-Dietrich S, Jogdand PS, Jepsen S, Pinto VV, Ditlev SB, Christiansen M, Larsen SO, Fox CB, Raman VS, Howard RF, Vedvick TS, Ireton G, Carter D, Reed SG, Theisen M.

Journal: Vaccine

Publication Date: April, 2011

Adjuvants for malaria vaccines

Authors: Coler RN, Carter D, Friede M, Reed SG.

Journal: Parasite Immuniology

Publication Date: September, 2009

Miscellaneous

Characterization of TLR4 agonist effects on alhydrogel® sedimentation: a novel application of laser scattering optical profiling

Authors: Fox CB.

Journal: Journal of Pharmaceutical Science

Publication Date: November, 2012

Vaccines to combat the neglected tropical diseases

Authors: Bethony JM, Cole RN, Guo X, Kamhawi S, Lightowlers MW, Loukas A, Petri W, Reed S, Valenzuela JG, Hotez PJ.

Journal: Immunological Reviews

Publication Date: January, 2011

The effect of limiting phosphate using the HMS174 cell line

Authors: Garner M, Vedvick T.

Journal: BioPharm International

Publication Date: July, 2010

Squalene Emulsions for Parenteral Vaccine and Drug Delivery

Authors: Fox CB.

Journal: Molecules

Publication Date: September, 2009

Nonionic surfactants formulated into drug and vaccine delivery systems

Authors: Chesko J, Anderson R, Fox C, Kalvodova L, Dutill T, Reed S, Vedvick TS.

Journal: Book: Non-Ionic Surfactants; ed. Pierce L Wendt and Demario S Hoysted

Publication Date: January, 2009

Vaccines for parasitic and bacterial diseases

Authors: Reed SG, Campos-Neto A.

Journal: Current Opinion in Immunology

Publication Date: August, 2003

Macrophage activation and inactivation in protozoal infections

Authors: Reed, S.G.

Journal: In Book: Hemopoietic Growth Factors and Mononuclear Phagocytes. R. van Furth, editor, Basel, Karger, pp 98-110.

Publication Date: January, 2003

Characterization of KLK4 expression and detection of KLK4-specific antibody in prostate cancer patient sera

Authors: Day CH, Fanger GR, Retter MW, Hylander BL, Penetrante RB, Houghton RL, Zhang X, McNeill PD, Filho AM, Nolasco M, Badaro R, Cheever MA, Reed SG, Dillon DC, Watanabe Y.

Journal: Oncogene

Publication Date: October, 2002

Serodiagnosis of human granulyoctic ehrlichiosis by using novel combinations of immunoreactive recombinant proteins

Authors: Lodes MJ, Mohamath R, Reynolds LD, McNeill P, Kolbert CP, Bruinsma ES, Benson DR, Hofmeister E, Reed SG, Houghton RL, Persing DH.

Journal: Journal of Clinical Microbiology

Publication Date: July, 2001

Serological expression cloning of novel immunoreactive antigens of Babesia microti

Authors: Lodes MJ, Houghton RL, Bruinsma ES, Mohamath R, Reynolds LD, Benson DR, Krause PJ, Reed SG, Persing DH.

Journal: Infection and Immunity

Publication Date: May, 2000

Human purified protein derivative-specific CD4+ T cells utilize both CD95-dependent and CD95-independent cytolytic mechanisms

Authors: Lewinsohn DM, Bement TT, Xu J, Lynch DH, Grabstein KH, Reed SG, Alderson MR.

Journal: Journal of Immunology

Publication Date: March, 1998

Interleukin-12 decreases HIV-1 replication in human macrophages reconstituted with autologous PBMC

Authors: Akridge RE, Reed SG.

Journal: Journal of Infectious Diseases

Publication Date: March, 1996

IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages.

Authors: Akridge RE, Oyafuso LK, Reed SG.

Journal: Journal of Immunology

Publication Date: December, 1994

Tuberculosis

Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment

Authors: Coler RN, Bertholet S, Pine SO, Orr MT, Reese V, Windish HP, Davis C, Kahn M, Baldwin SL, Reed SG.

Journal: Journal of Infectious Diseases

Publication Date: April, 2013

A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis

Authors: Ollinger J, Bailey MA, Moraski GC, Casey A, Florio S, Alling T, Miller MJ, Parish T.

Journal: PLoS One

Publication Date: April, 2013

Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives

Authors: Kumar D, Raj KK, Bailey M, Alling T, Parish T, Rawat DS.

Journal: Bioorganics and Medicinal Chemistry Letters

Publication Date: January, 2013

BCG: myths, realities, and the need for alternative vaccine strategies

Authors: McShane H, Jacobs WR, Fine PE, Reed SG, McMurray DN, Behr M, Williams A, Orme IM.

Journal: Tuberculosis (Edinb).

Publication Date: May, 2012

The importance of adjuvant formulation in the development of a tuberculosis vaccine

Authors: Baldwin SL, Bertholet S, Reese VA, Ching LK, Reed SG, Coler RN.

Journal: Journal of Immunology

Publication Date: March, 2012

Inhibition of the Sole Type I Signal Peptidase of Mycobacterium tuberculosis Is Bactericidal under Replicating and Nonreplicating Conditions

Authors: Ollinger J, O'Malley T, Ahn J, Odingo J, Parish T.

Journal: Journal of Bacteriology

Publication Date: March, 2012

Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target

Authors: Ollinger J, O'Malley T, Kesicki EA, Odingo J, Parish T.

Journal: Journal of Bacteriology

Publication Date: February, 2012

Protection of mice from Mycobacterium tuberculosis by ID87/GLA-SE, a novel tuberculosis subunit vaccine candidate

Authors: Windish HP, Duthie MS, Ireton G, Lucas E, Laurance JD, Bailor RH, Coler RN, Reed SG.

Journal: Vaccine

Publication Date: October, 2011

Effect of chemotherapy on whole-blood cytokine responses to Mycobacterium tuberculosis antigens in a small cohort of patients with pulmonary tuberculosis

Authors: Bertholet S, Horne DJ, Laughlin EM, Savlov M, Tucakovic I, Coler RN, Narita M, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: August, 2011

Identifying vulnerable pathways in Mtb by using a knockdown approach

Authors: Carroll P, Faray-Kele MC, Parish T.

Journal: Applied and Environmental Microbiology

Publication Date: July, 2011

Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis

Authors: Roberts G, Vadrevu IS, Madiraju MV, Parish T.

Journal: Plos One

Publication Date: June, 2011

Mycobacterium tuberculosis Rv0198c, a putative matrix metalloprotease is involved in pathogenicity

Authors: Muttucumaru DG, Smith DA, McMinn EJ, Reese V, Coler RN, Parish T.

Journal: Tuberculosis

Publication Date: March, 2011

A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobaterium tuberculosis

Authors: Bertholet S, Ireton GC, Ordway DJ, Windish HP, Pine SO, Kahn M, Phan T, Orme IM, Vedvick TS, Baldwin SL, Coler RN, Reed SG.

Journal: Science Translational Medicine

Publication Date: October, 2010

Identification of Mycobacterium tuberculosis antigens of high serodiagnostic value

Authors: Ireton GC, Greenwald R, Liang H, Esfandiari J, Lyashchenko KP, Reed SG.

Journal: Clinical and Vaccine Immunology

Publication Date: October, 2010

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories

Authors: Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR Jr, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC.

Journal: Journal of Bacteriology

Publication Date: July, 2010

Optimisation of bioluminescent reporters for use with mycobacteria

Authors: Andreu N, Zelmer A, Fletcher T, Elkington PT, Ward TH, Ripoll J, Parish T, Bancroft GJ, Schaible U, Robertson BD, Wiles S.

Journal: Plos One

Publication Date: May, 2010

The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally-regulated by Dxs activity

Authors: Brown AC, Eberl M, Crick DC, Jomaa H, Parish T.

Journal: Journal of Bacteriology

Publication Date: May, 2010

Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters

Authors: Carroll P, Schreuder LJ, Muwanguzi-Karugaba J, Wiles S, Robertson BD, Ripoll J, Ward TH, Bancroft GJ, Schaible UE, Parish T.

Journal: Plos One

Publication Date: March, 2010

The Arabinosyltransferase EmbC Is Inhibited by Ethambutol in Mycobacterium tuberculosis

Authors: Goude R, Amin AG, Chatterjee D, Parish T.

Journal: Antimicrobial Agents and Chemotherapy

Publication Date: October, 2009

Intradermal immunization improves protective efficacy of a novel TB vaccine candidate

Authors: Baldwin SL, Bertholet S, Kahn M, Zharkikh I, Ireton GC, Vedvick TS, Reed SG, Coler RN.

Journal: Vaccine

Publication Date: May, 2009

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

Authors: Reed SG, Coler RN, Dalemans W, Tan EV, DeLa Cruz EC, Basaraba RJ, Orme IM, Skeiky YA, Alderson MR, Cowgill KD, Prieels JP, Abalos RM, Dubois MC, Cohen J, Mettens P, Lobet Y.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Publication Date: February, 2009

Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning

Authors: Coler RN, Dillon DC, Skeiky YA, Kahn M, Orme IM, Lobet Y, Reed SG, Alderson MR.

Journal: Vaccine

Publication Date: January, 2009

Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis

Authors: Bertholet S, Ireton GC, Kahn M, Guderian J, Mohamath R, Stride N, Laughlin EM, Baldwin SL, Vedvick TS, Coler RN, Reed SG.

Journal: Journal of Immunology

Publication Date: December, 2008

The Genetics of Cell Wall biosynthesis in Mycobacterium tuberculosis

Authors: Goude R, Parish T.

Journal: Future Microbiology

Publication Date: June, 2008

Reducing the global burden of tuberculosis: the contribution of improved diagnostics

Authors: Keeler E, Perkins MD, Small P, Hanson C, Reed S, Cunningham J, Aledort JE, Hillborne L, Rafael ME, Girosi F, Dye C.

Journal: Nature

Publication Date: November, 2006

Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis

Authors: Tsenova L, Harbacheuski R, Moreira AL, Ellison E, Dalemans W, Alderson MR, Mathema B, Reed SG, Skeiky YA, Kaplan G.

Journal: Infection and Immunity

Publication Date: April, 2006

Cloning of the gene encoding a protective Mycobacterium tuberculosis secreted protein detected in vivo during the initial phases of the infectious process

Authors: Mukherjee S, Kashino SS, Zhang Y, Daifalla N, Rodrigues V Jr, Reed SG, Campos-Neto A.

Journal: Journal of Immunology

Publication Date: October, 2005

Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein

Authors: Irwin SM, Izzo AA, Dow SW, Skeiky YA, Reed SG, Alderson MR, Orme IM.

Journal: Infection and Immunity

Publication Date: September, 2005

Protection of mice and guinea pigs against tuberculosis induced by immunization with a single Mycobacterium tuberculosis recombinant antigen, MTB41

Authors: Skeiky YA, Alderson MR, Ovendale PJ, Lobet Y, Dalemans W, Orme IM, Reed SG, Campos-Neto A.

Journal: Vaccine

Publication Date: June, 2005

Skin test performed with highly purified Mycobacterium tuberculosis recombinant protein triggers tuberculin shock in infected guinea pigs

Authors: Reece ST, Stride N, Ovendale P, Reed SG, Campos-Neto A.

Journal: Infection and Immunity

Publication Date: June, 2005

The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs

Authors: Brandt L, Skeiky YA, Alderson MR, Lobet Y, Dalemans W, Turner OC, Basaraba RJ, Izzo AA, Lasco TM, Chapman PL, Reed SG, Orme IM.

Journal: Infection and Immunity

Publication Date: November, 2004

Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein

Authors: Skeiky YA, Alderson MR, Ovendale PJ, Guderian JA, Brandt L, Dillon DC, Campos-Neto A, Lobet Y, Dalemans W, Orme IM, Reed SG.

Journal: Journal of Immunology

Publication Date: June, 2004

Potential serological use of a recombinant protein that is a replica of a Mycobacterium tuberculosis protein found in the urine of infected mice

Authors: Mukherjee S, Daifalla N, Zhang Y, Douglass J, Brooks L, Vedvick T, Houghton R, Reed SG, Campos-Neto A.

Journal: Clinical and Diagnostic Laboratory Immunology

Publication Date: March, 2004

Expression and purification of immunologically reactive DPPD, a recombinant Mycobacterium tuberculosis skin test antigen, using Mycobacterium smegmatis and Escherichia coli host cells

Authors: Liu C, Flamoe E, Chen HJ, Carter D, Reed SG, Campos-Neto A.

Journal: Canadian Journal of Microbiology

Publication Date: February, 2004

Prospects for a better vaccine against tuberculosis

Authors: Reed SG, Alderson MR, Dalemans W, Lobet Y, Skeiky YA.

Journal: Tuberculosis (Edinburgh, Scotland)

Publication Date: January, 2003

Serological expression cloning and immunological evaluation of MTB48, a novel Mycobacterium tuberculosis antigen

Authors: Lodes MJ, Dillon DC, Mohamath R, Day CH, Benson DR, Reynolds LD, McNeill P, Sampaio DP, Skeiky YA, Badaro R, Persing DH, Reed SG, Houghton RL.

Journal: Journal of Clinical Microbiology

Publication Date: July, 2001

Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis

Authors: Coler RN, Campos-Neto A, Ovendale P, Day FH, Fling SP, Zhu L, Serbina N, Flynn JL, Reed SG, Alderson MR.

Journal: Journal of Immunology

Publication Date: May, 2001

Evaluation of DPPD, a single recombinant Mycobacterium tuberculosis protein as an alternative antigen for the Mantoux test

Authors: Campos-Neto A, Rodrigues-Júnior V, Pedral-Sampaio DB, Netto EM, Ovendale PJ, Coler RN, Skeiky YA, Badaró R, Reed SG.

Journal: Tuberculosis (Edinburgh, Scotland)

Publication Date: January, 2001

Classically restricted human CD8+ T lymphocytes derived from Mtb infected cells: definition of antigenic specificity

Authors: Lewinsohn DM, Zhu L, Madison VJ, Dillon DC, Fling SP, Reed SG, Grabstein KH, Alderson MR.

Journal: Journal of Immunology

Publication Date: January, 2001

T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection

Authors: Skeiky YA, Ovendale PJ, Jen S, Alderson MR, Dillon DC, Smith S, Wilson CB, Orme IM, Reed SG, Campos-Neto A.

Journal: Journal of Immunology

Publication Date: December, 2000

Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium bovis BCG

Authors: Dillon DC, Alderson MR, Day CH, Bement T, Campos-Neto A, Skeiky YA, Vedvick T, Badaro R, Reed SG, Houghton R.

Journal: Journal of Clinical Microbiology

Publication Date: September, 2000

Mycobacterium tuberculosis-reactive CD8+ T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction

Authors: Lewinsohn DM, Briden AL, Reed SG, Grabstein KH, Alderson MR.

Journal: Journal of Immunology

Publication Date: July, 2000

Cloning of a Mycobacterium tuberculosis gene encoding a PPD protein that elicits strong tuberculosis specific delayed type hypersensitivity

Authors: Coler RN, Skeiky YA, Ovendale PJ, Vedvick TS, Gervassi L, Guderian J, Jen S, Reed SG, Campos-Neto A.

Journal: Journal of Infectious Diseases

Publication Date: July, 2000

Mass Spectrometric identification of Mtb81: a novel serological marker for tuberculosis

Authors: Hendrickson RC, Douglass JF, Reynolds LD, McNeill PD, Carter D, Reed SG, Houghton RL.

Journal: Journal of Clinical Microbiology

Publication Date: June, 2000

Expression cloning of an immunodominant family of Mycobacterium tuberculosis antigens using human CD4+ T cells

Authors: Alderson MR, Bement T, Day CH, Zhu L, Molesh D, Skeiky YA, Coler R, Lewinsohn DM, Reed SG, Dillon DC.

Journal: Journal of Experimental Medicine

Publication Date: February, 2000

Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis

Authors: Skeiky YA, Lodes MJ, Guderian JA, Mohamath R, Bement T, Alderson MR, Reed SG.

Journal: Infection and Immunity

Publication Date: August, 1999

Molecular characterization and human T cell responses to a member of a novel Mycobacterium tuberculosis Mtb39 gene family

Authors: Dillon DC, Alderson MR, Day CH, Lewinsohn DM, Coler R, Bement T, Campos-Neto A, Skeiky YA, Orme IM, Roberts A, Steen S, Dalemans W, Badaro R, Reed SG.

Journal: Infection and Immunity

Publication Date: June, 1999

Molecular cloning and immunological reactivity of a novel low-molecular-mass antigen of Mycobacterium tuberculosis

Authors: Coler RN, Skeiky YA, Vedvick T, Bement T, Ovendale P, Campos-Neto A, Alderson MR, Reed SG.

Journal: Journal of Immunology

Publication Date: September, 1998

Molecular cloning, expression and immunogenicity of MTB12, a novel low molecular weight secreted antigen of Mycobacterium tuberculosis

Authors: Webb JR, Vedvick TS, Alderson MR, Guderian JA, Jen SS, Ovendale PJ, Johnson SM, Reed SG, Skeiky YA.

Journal: Infection and Immunity

Publication Date: September, 1998

Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen presenting cells

Authors: Lewinsohn DM, Alderson MR, Briden AL, Riddell SR, Reed SG, Grabstein KH.

Journal: Journal of Experimental Medicine

Publication Date: May, 1998

Antigens shared by Leishmania species and Trypanosoma cruzi: immunological comparison of the acidic ribosomal P0 proteins

Authors: Skeiky YA, Benson DR, Elwasila M, Badaro R, Burns JM Jr, Reed SG.

Journal: Infection and Immunity

Publication Date: May, 1994